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The lower K i value means higher binding affinity, whereas higher K i value means lower binding affinity

As for ligand-gated ion channels such as GABA A and glutamate NMDA receptors, GABRA1, GABRB3, and GABRG2 mutations encoding 1, 3, and 2 subunits of GABA A receptor, and GRIN1, GRIN2A, GRIN2B, and GRIN2D mutations encoding NR1, NR2A, NR2B, and NR2D subunits of NMDA receptors, respectively, have been identified in genetic epilepsy [27]

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Tissue-specific regulation of cytochrome c by post-translational modifications: respiration, the mitochondrial membrane potential